| abstract |
The invention relates to methods of evaluating MS severity based on analysis of single nucleotide polymorphisms (SNPs) and to products and kits for use in such methods. The methods include a method of assessing a multiple sclerosis disease severity phenotype in a human subject having multiple sclerosis, by determining the genotype of the subject at one or more positions of single nucleotide polymorphism (SNP) selected from: rs 2107538, rs 1137933, rs 1318, rs 2069763, rs 423904, rs 876493, rs 10243024, rs 10259085, rs 1042173, rs 10492503, rs 10492972, rs 12047808, rs 12202350, rs 12861247, rs 13353224, rs 1350666, rs 1555322, rs 1611115, rs 17641078, rs 1805009, rs 2028455, rs 2032893, rs 2049306, rs 2066713, rs 2074897, rs 2076530, rs 2187668, rs 2213584, rs 2227139, rs 2234978, rs 2239802, rs 2395182, rs 260461, rs 28386840, rs 3087456, rs 3135388, rs 3741981, rs 3756450, rs 3781202, rs 3787283, rs 3808585, rs 4128767, rs 4404254, rs 4473631, rs 4680534, rs 6077690, rs 6457594, rs 6570426, rs 659366, rs 6917747, rs 7208257, rs 7528684, rs 7577925, rs 762550, rs 7956189, rs 7995215, rs 8049651, rs 8702, rs 9808753 and rs 987107, and/or a SNP in linkage disequilibrium with any one of said SNPs. |