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filingDate 2009-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7182e9c16a652e7dbf30bc0ead271ac
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publicationDate 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2012040848-A2
titleOfInvention Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen
abstract The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8628920-B2
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