| abstract |
The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula VIII n n n n n n n n n n in which at least one of the groups X 1 , X 2 , X 3 is selected fromn fluoro, chloro, bromo, hydroxy, methoxy, ethoxy, trifluoromethyl, amino whereas the other groups X 1 , X 2 , X 3 have the meaning of a hydrogen atom, in which at least one of the groups Z 1 , Z 2 , Z 3 is selected from —O—, —S—, —NH—, —N(—CH 3 )—, whereas the other groups Z 1 , Z 2 , Z 3 have the meaning of a —CH 2 — group,n nand in which Ar is an aromatic group. |