Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebc1a0a2c0621c25d94b7dd16996160a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2097a123491d5b60d4d46a42c683046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4f50c133a46e67f8708b75be23fe86e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07d04c30739c1a97585f0fa306ad3d23 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-60 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
filingDate |
2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9dbc0180e80f3d9d89fe5adc69d7dab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fd07710e88be4911f8530b23c24a5b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f42e95785052e47c543b7ece1e3f848d |
publicationDate |
2012-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2012035079-A1 |
titleOfInvention |
Genotoxicity testing |
abstract |
The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding Gaussia luciferase (GLuc) reporter protein operatively linked to a human GADD45α gene promoter and a human GADD45α gene regulatory element arranged to activate expression of the DNA sequence in response to DNA damage) to an agent; and monitoring the expression of the GLuc reporter protein from the cell. The invention also concerns expression cassettes, vectors and cells which may be used according to such a method and also modified media that may be employed in assays and in preferred embodiments of the method of the invention. |
priorityDate |
2009-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |