| abstract |
The present invention relates to a process for the manufacturing of 5-substituted 3-aryl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrroles of formula (I) n n n n n n n n n n which comprises the following steps:n (i) reacting a compound of formula (II) with a isonitrile compound of formula (III) nn n n n n n n n n n in the presence of a metal catalyst to obtain compounds of formula (IV) n n n n n n n n n n n n (ii) isomerizing compounds of formula (IV) to obtain compounds of formula (V) and n n n n n n n n n n n n (iii) reacting the dihydropyrrole compound of formula (V) under acidic conditions, to obtain the compounds of formula (I), wherein X, n, Z, Y, and T are as defined in the description. |