abstract |
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): n n n n n n n n n n wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;n nE is lower alkylene;n nX is S, O, or NR 1 ;n nR 1 is a hydrogen atom or lower alkyl;n nR 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom, halogen, or hydroxy etc.;n nn and m are each independently an integer of 0 to 3;n nn+m is an integer of 0 to 3;n nR 5 is a hydrogen atom or substituted lower alkyl;n nits pharmaceutically acceptable salt, or a solvate thereof. |