| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb71e8a3aacdcdf0d43fa980fd59cb97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e63611061494caeb807156e65e47d751
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3d69da840d3d4298eb267e998cc8f36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d39d5bff2effa2c39584d39fade723aa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-467 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 |
| filingDate |
2011-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb494d5a48891c4ed4632266d140b86d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39ddb3d91871350e1295f0271333596b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_860fe2af5b273e56383744c099f1acb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebb8e7b1f98780d829ca2fe010e44f68 |
| publicationDate |
2012-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2012003671-A1 |
| titleOfInvention |
Methods for antibody engineering |
| abstract |
The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of a number of related antibodies that each bind to the same antigen as the parent antibody. The amino acid at the substitutable position may be substituted for a different amino acid without significantly affecting the activity of the antibody. The subject methods may be employed to change the amino acid sequence of a CDR without significantly reducing the affinity of the antibody of the antibody, in humanization methods, or in other antibody engineering methods. The invention finds use in a variety of therapeutic, diagnostic and research applications. |
| priorityDate |
2004-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |