| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc1c758cfd5b55f844c478d96be7c99c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a341fb08e93884657c045563ea7655b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5de66fcc7c37934b48c684ca26e9cc0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a9c3414af0f62a8b5419d40bdc0407a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78ab05925dd343874f4279d9d989fd65 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-485 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2010-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_735e4057b097426430a55b5e5b98fe96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0eed232142b030c69efe18e1441c4e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3993bccb2c5aecbcf28ddb22f1e1732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8007b1b5e27d58c409b80861fb6d694d |
| publicationDate |
2011-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011318787-A1 |
| titleOfInvention |
Means and methods for modulating notch3 protein expression and/or the coding region of notch3; compositions and use thereof in the treatment of cadasil |
| abstract |
The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 m RNA or pre-m RNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 m RNA or pre-m RNA. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10407500-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114062682-A |
| priorityDate |
2009-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |