| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ac656a6e2f3adc6c1b2d1276422116a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3636778be6a7ac40989c4529d124baa1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_731b97bad7b728f4f7e71535329bcf52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbc3e7608ac2c1394aecf40e0e34b852 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-11 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8281
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8261
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8251
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8285
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8279
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8274
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8218
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8247
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8246 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01H5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2011-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49f83cf34f68767af6689e3335fa5209
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_218832bead19a8fa355d6bac4748e300 |
| publicationDate |
2011-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011314571-A1 |
| titleOfInvention |
Method to trigger rna interference |
| abstract |
A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely double-stranded RNA. Rather, the method depends on constructs that yield single-stranded RNA transcripts, and exploits endogenous or in vivo-produced miRNAs or siRNAs to initiate production of siRNAs. The miRNAs or siRNAs guide cleavage of the transcript and set the register for production of siRNAs (usually 21 nucleotides in length) encoded adjacent to the initiation cleavage site within the construct. The method results in specific formation of siRNAs of predictable size and register (phase) relative to the initiation cleavage site. The method can be used to produce specific siRNAs in vivo for inactivation or suppression of one or more target genes or other entities, such as pathogens. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773455-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10980356-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108348166-A |
| priorityDate |
2005-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |