| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b7de3691b68716e22f5af5542ac2e62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f286963ef142c864e0ab0f87cc7aa13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-02 |
| filingDate |
2010-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09bfa73cf039764034f6260284f2a89a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93fbe777a2928a8511792aa55e744795 |
| publicationDate |
2011-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011313164-A1 |
| titleOfInvention |
Lithium derivatives of pyrroloquinoline quinone and preparation method thereof |
| abstract |
Lithium derivatives of pyrroloquinoline quinone and preparation method thereof are disclosed. In said method, lithium derivatives of pyrroloquinoline quinone are obtained by an acid-base neutralization reaction in a basic solvent with pyrroloquinoline quinine (PQQ) as a starting material. Lithium ion is brought in the molecular structure of pyrroloquinoline quinone to form said lithium derivatives of pyrroloquinoline quinone. The reaction condition of said method is mild, the product is easy to be purified, the preparation procedure is simple, and the yield is more than 80%. Said lithium derivatives of pyrroloquinoline quinone possess GSK-3 inhibiting activity and possess the functions such as reducing the formation of age pigment in the brain of a transgenic mouse and reducing the phosphorylation of tau proteins. Said lithium derivatives of pyrroloquinoline quinone may be used in the manufacture of medicaments for preventing and treating senile dementia, senility or Parkinson's disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394298-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8946423-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014027669-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738639-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3919125-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016137641-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9321770-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012116087-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163014-B2 |
| priorityDate |
2009-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |