abstract |
A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, a reagent reservoir containing a reagent for addition to the biological sample, and, a hybridization chamber containing probes having a nucleic acid sequence for hybridization with the target nucleic acid sequence to form probe-target hybrids, wherein, microsystems tech the reagent reservoir has a volume less than 1,000,000,000 cubic microns and the hybridization chamber has a volume less than 900,000 cubic microns. |