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publicationDate 2011-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2011306102-A1
titleOfInvention Improved methods for fermentative production of docosahexaenoic acid
abstract The invention comprises a process of producing polyunsaturated fatty acids from Thraustochytriales at high availability of oxygen by solid state fermentation or submerged fermentation in a batch, semi-continuous or continuous mode. Batch fermentation of more than 200 g/L and up to 450 g/L of dextrose added right in the beginning of fermentation was achieved with productivity of DHA achieved for higher than 10 g/Liter. The process comprises maintaining at least 20% to 30% dissolved oxygen and sometimes up to around 50% or more.
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