| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f935b84827ff4a3e441c3f219d841de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_269608716630f7707dac8e21297abc97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69f8a2cb5a2fc61555885b676bac2f66 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2795-00043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-554
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2011-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd77e59944789beac255b46079582350
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_111996acf5542eac1077e8ebe040f86f |
| publicationDate |
2011-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011287971-A1 |
| titleOfInvention |
Multi-chain eukaryotic display vectors and uses thereof |
| abstract |
A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9034601-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9068980-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9645146-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9116149-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011009280-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011190159-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9012181-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9005927-B2 |
| priorityDate |
2001-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |