| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95cba80ebbf1517306d8c6cba42b59f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4f2d0f6a6161efb05b2ef69fab54ff42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f1ab60393ecb1347289a870f153fce4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C305-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate |
2010-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35239252b6ae5ca19e6a64c6510c8177
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a2e4456d10d3d7c6581cf65d9dc02d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da728ef2fc196d08b9a6fef6982220b7 |
| publicationDate |
2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011275719-A1 |
| titleOfInvention |
Novel trifluoromethylsulfonamide gamma secretase inhibitor |
| abstract |
The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11370823-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016069906-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3970725-A1 |
| priorityDate |
2009-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |