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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-559
filingDate 2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83b9d93eac69c9ba927958b3deb9e818
publicationDate 2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2011259744-A1
titleOfInvention Sensors for biomolecular detection and cell classification
abstract A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample ( 5 ) comprising an ionic analyte and a detection reagent in a conductive fluid, wherein the detection reagent has a net charge different from the analyte; (b) a first permeable polymeric hydrogel plate ( 3 ) and a first spacer plate ( 8 ), which plates provide a compartment for the sample; (c) an anode (1) juxtaposed to the outside of the first hydrogel plate and not in contact with the sample; (d) a cathode ( 9 ) juxtaposed to the outside of the first spacer plate and not in contact with the sample; (e) a voltage generator ( 10 ) to apply an electric potential to the anode and cathode; and (f) a detector ( 11 ). The bound complex formed from the analyte and detection reagent is detected by the detector because the bound complex has a charge that causes it to migrate in a direction opposite from that of the unbound analyte when the electric potential is applied. The present invention further methods for new rapid clinical uses such as for pap smears, diagnosis of sexually transmitted diseases, diagnoses of skin cancers, diagnosis of oral cancers and monitoring lymphocytes.
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