http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011257399-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16b79365dd4a1657c26540b8a2527109 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79c2cd540fd9c40191dc4c5757ede947 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2010-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a99d647cdca252936fffb3e71a3622d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb6d1be04347348281fd4ed031c25096 |
| publicationDate | 2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2011257399-A1 |
| titleOfInvention | Fluorescent calcium indicators that are ratiometric and emit in the red spectrum |
| abstract | A new generation of fluorescent ion indicators for measuring cytosolic concentrations of calcium. These new indicators emit in the red portion of the visible spectrum and are ratiometric. The ratiometry consists of shifting in the emission upon binding calcium when exciting with an argon laser at 488 nm. These indicators also show marked increases in red fluorescence when excited with visible light at longer wavelengths. Like all calcium indicators, they comprise the usual chelating portion based on BAPTA (Bis Amino Phenyl Tetraacetic Acid) and a fluorophore portion, either a seminaphthofluorescein/seminaphthorhodamine or dinaphthofluorescein, which enable ratiometry. Unlike other naphthofluoresceins, the pKa has been adjusted on the naphtho moiety to make it suitable for biological calcium measurements. The invention relates to the structures of the indicators and to the method of synthesizing these indicators. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11388914-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013260349-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10104903-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9111461-B2 |
| priorityDate | 2009-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.