| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b28cc4dff22c39966f55eedc1106a4c4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
2011-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ec1088a3e8bcf391bfa17f82ad675ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef75266d3e972773dbb77ec510e5f55f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f70ed85c1dafe61fd487a8895742cce5 |
| publicationDate |
2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011256604-A1 |
| titleOfInvention |
Generation of asporogenous solventogenic clostridia |
| abstract |
Expression of the SpoIIE gene in a solventogenic Clostridium cell is silenced and sporulation is abolished. The cell exhibits increased production of a solvent, such as butanol, relative to a wild-type solventogenic Clostridium cell and can be used for industrial-scale production of a chemical product. A method includes silencing the SpoIIE gene of the Clostridium cell via a homologous recombination method in which a resolvase gene is expressed. Another method includes increasing solvent production in bacterial cells by inoculating the cells with an inoculum of exponentially growing cells, wherein expression of a sporulation gene in the bacterial cells is inhibited or silenced and the cells of the inoculum are in a post-exponential phase of growth prior to inoculation. |
| priorityDate |
2010-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |