http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011245497-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a615b6db0acb71ee30f71f157888ba2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D411-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D411-04 |
| filingDate | 2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02e6d61a214939698206afd721cdaa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c12c6815af885117b3514cdb7765cae2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9147d21e9f2b1f28b5885e4db5455e0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0e066f2accd3ce7b492101fd3dc5000 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5034584431b4aa977826971a4668f656 |
| publicationDate | 2011-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2011245497-A1 |
| titleOfInvention | Optical resolution of substituted 1, 3-oxathiolane nucleosides |
| abstract | Cis(±)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone is reacted with S(+)-1,1′-binaphthyl-2,2′-diyl hydrogen phosphate in methanol to obtain diastereomeric compounds. The diastereomeric compounds are subjected to selective crystallization to obtain (2R-Cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate. (2R-Cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate is treated with hydrochloric acid in water to obtain (2R-cis)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone. |
| priorityDate | 2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.