| abstract |
A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N-di(C 1 -C 8 )alkylamino substituted, (C 4 -C 18 )alkyl(C 2 -C 18 )carboxylic ester a (C 1 -C 4 )-alkyl(C 8 -C 22 )carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C 1 -C 8 )alkylamino substituted, (C 4 -C 18 )alkyl(C 2 -C 18 ) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP). |