| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4465d64ba7d7a76999eceb0bba797f58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4781a4ea06b1dba2843cd3f86e22f95b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a9dfb473149996e4b79e48c8dc6af45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3653d84bbc53fe7f976cc3942ae47b2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-726
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-728
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0078 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate |
2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ff43a04128ea7bd511f43a410e9a3f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9754828dcae7f24c2edc836a115688c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd5a069734ef4f57344371b7f6b8d80c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfdfe70a8691d3adf1a7e297d6d0a1cf |
| publicationDate |
2011-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011236381-A1 |
| titleOfInvention |
Inhibition of inter-alpha trypsin inhibitor for the treatment of airway disease |
| abstract |
It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease. Provided herein are methods of treating an airway disease or disorder in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. Also provided is a method of preventing or reducing airway hyperresponsiveness in a subject by administering to the subject a therapeutically effective amount of an inhibitor of IaI. The IaI inhibitor can be any compound that inhibits the expression or activity of IaI or a gene encoding an IaI polypeptide. In some embodiments, the IaI inhibitor is administered locally to the airway of the subject in need of treatment. For example, the inhibitor can be administered by aerosol delivery, such as by using an inhaler or nebulizer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9572872-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10076559-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10258675-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11471617-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015238578-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9758570-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE47972-E |
| priorityDate |
2008-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |