| abstract |
Provided are fusion proteins of apoptin-protein transduction domain of carboxyl-terminus of EC-SOD, their encoding genes, the recombinant vectors containing said encoding genes, transformants containing said recombinant vectors, as well as the uses and preparation methods thereof. Especially provided are fusion proteins which fuse protein transduction domain of carboxyl-terminus of EC-SOD in the amino acid sequence of SEQ ID NO:1 or its mutants and apoptin in the amino acid sequence of SEQ ID NO:2 or its mutants, said fusion proteins have strong ability of inducing apoptosis of tumor cells, and can be used for manufacturing of medicament for the treatment of tumors. |