| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_943d21326a8034afdb808ab726293c7d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-39 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 |
| filingDate |
2010-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1ad9ad932a3b2ebc1a59ff7c8c5a46f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08d9bc803911abe3e185dc29860acfbe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a09e053c87a7d5e750e6d13b9513db78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02630bff96c73a5636bfe02330e2d28d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f85b6af714713c1a5688eb3644ccb6aa |
| publicationDate |
2011-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011217773-A1 |
| titleOfInvention |
Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro |
| abstract |
The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018143286-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160124806-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111108189-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018232459-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102421950-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017152172-A1 |
| priorityDate |
2010-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |