http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011201028-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98ff0aa38a3f2bd2b4e49a1152467ab9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2011-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15da3d46c48bef4701232c65fcbbdc46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cac7b69ba70b2ddb2f09d2a8198db25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2431d6805fc9f3b4a3c86e12d4b1cd61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74b77e36e7293e33b3adc84dfc13e97e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_998ae76707297df0e7fb4b6579343202 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8b0d1f38e7e7ee908bf9b9a0f86e882 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e122f58b31362f20352379f73d6bbcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81caafda9a355cd51772f5ba8b9864f8 |
| publicationDate | 2011-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2011201028-A1 |
| titleOfInvention | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| abstract | The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. n Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. n Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. n Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8802379-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011081658-A1 |
| priorityDate | 2001-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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