http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011200581-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2c228216107399365de2b258890d1c3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2010-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_241407387e461eadf179f08dd2caf37d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e2bb543d474c35cc4040386ace48b3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5845bf4152f149339c40de231f96280 |
| publicationDate | 2011-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2011200581-A1 |
| titleOfInvention | Pharmaceutical compositions |
| abstract | Synthesis natural tubulisine derivatives of formula (A) having a high cytotoxicity wherein: B is selected from CH2, CH2—CH2 or CH2—CH2—CH2, D is an aromatic linker, X1 is alkyl or alkenyl, X2 is selected from the X2a, substituted or non substituted, selected from: aryl, heteroaryl, arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, or heteroarylalkyl, X2b: alkylene-O-alkyl, wherein alkylene is C2-C10, X2c: CH2—O-alkyl, X3 is selected from H, or together with X4 forms the group ═O, X4 is selected from H, halogen, OH, SH, alkyl, alkenyl, (OR5)n—OR6, OC(O)R7, NR6R7, or together with X4 forms the group ═O, R5 is an alkylene, n is zero or an integer from 1 to 10, R6 and R7, equal to or different from each other, have the following meanings: z1: H, alkyl, z2 substituted or non substituted: aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, X5 is z2, or has the meaning of z3=alkyl, alkenyl, X6 is selected from NR8R9, OR8, NH—NR8R9, SR8, R10, wherein R8 and R9, equal to or different from each other, have the same meanings of R8, R10 has the same meanings as R6 but excluding H, X7 is z3 or H, X8 is selected from z3, H, halogen, OH, SH, OCH3. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10808007-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107459532-A |
| priorityDate | 2009-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 2523.