Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c9ecc512af20429f73818bcd7737bbea |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
filingDate |
2010-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2b2e969faec7a68a254fca386069ac7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65fd088207b29b27d1909a8d0f741ded |
publicationDate |
2011-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2011184050-A1 |
titleOfInvention |
Methods and means for treating dna repeat instability associated genetic disorders |
abstract |
The current invention provides for methods and medicaments that apply an oligonucleotide comprising aninosine and/or an uracile and/or a nucleotide containing a base able to form a wobble base pair, said oligonucleotide being preferably RNAse H substantially independent and being complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to a modified oligonucleotide which can be applied in a method of the invention to prevent the accumulation and/or translation of repeat expanded transcripts in cells. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11179411-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10758558-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9745576-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2013253074-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459564-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11274299-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10689646-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11345915-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015023937-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10876114-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015148404-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10913946-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11427820-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2013253074-B2 |
priorityDate |
2008-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |