abstract |
Potent and selective ligands for the dopamine 3 (D 3 ) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is CāO or SO 2 , R 1 is C 1-6 alkyl, R 2 is aryl, heteroaryl, aryl, ā(CH 2 ) 1-3 aryl, or ā(CH 2 ) 1-3 heteroaryl, and n is 0 or 1. Methods of using the D 3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D 3 receptor provides a benefit also are disclosed. |