| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-60 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137 |
| filingDate |
2009-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_045e856d38240bb8b069830349291866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e13f5514fa42ebfb804c3bcc5c58a4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cb53a3ffec095677047a8c70b40255e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f44b88f795e587053ca53040cb30f49f |
| publicationDate |
2011-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011166237-A1 |
| titleOfInvention |
Process for the Synthesis of Arformoterol |
| abstract |
The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R 1 and R 2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10005743-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9434703-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9403783-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011251198-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115873909-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160733-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9402854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015080358-A1 |
| priorityDate |
2008-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |