| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f3e3523d0d029abbd841f3e54530dd7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1481d15afd3f2bb0d80d68891710295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ca151330513e18c6bde373050e0dc43 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1133
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 |
| filingDate |
2009-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b2cd0412d7d4c11bc2c4df1ba4ef03c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d90f2acd66e93d7383db391192338318
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_620cbb72b9d3b39a8ac150b82cd2a41e |
| publicationDate |
2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011144304-A1 |
| titleOfInvention |
Chemical Modification of Proteins |
| abstract |
The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180026350-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018044130-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10723760-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013084198-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102037956-B1 |
| priorityDate |
2008-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |