| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f132c8e9f2f3b103e8acdb98cd142ca6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec9ea35f3b11bb0867198d5f36a5d17b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1359893bcca390132d2d5ede3091980e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-782 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-4906
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-553
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-661
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
2008-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_baa6a6b3ebe738ec31093cd32b17a923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cdb8ed83b021b004875645d69c99947
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c69ba1f48e5436ac7115356687f260b |
| publicationDate |
2011-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011124607-A1 |
| titleOfInvention |
Composition for regulation cellular senescence comprising lysophosphatidic acid and inhibitor of adenylyl cyclase as active ingredients |
| abstract |
The present invention relates to the molecular mechanism inducing cell proliferation in aged human fibroblasts by inhibiting AMPK using LPA and AC inhibitor. Particularly, the present invention relates to a composition comprising LPA and ACI as active ingredients and the invention proves with the said composition that LPA and ACI regulate different phosphorylation of AMPKα and thus inactivate p53 and induce senescent cell proliferation. This results support the fact that AMPK signal transduction plays an important role in cell proliferation of senescent cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9969776-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10745445-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012083472-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9884065-B2 |
| priorityDate |
2008-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |