| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_723d67cc27bf0e0d208f61e7cb04cc6a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_211ab1455edeb040ae74716441ef618d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_992d8e2b644ab21260ad23fb868613b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_789ff5758411a31ded99ce996e9142fb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-653
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-653 |
| filingDate |
2007-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a7f5d556d6707e3c05c79fa55db01bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b56b672bfdfb1d62a13274e4ad1302ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_813da16e29ea363acfba1b75885a6b31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81ed6d48a2cd011ca55f3313bd97dfc4 |
| publicationDate |
2011-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011124602-A1 |
| titleOfInvention |
Stat3 Inhibitor Having Anti-Cancer Activity and Methods |
| abstract |
A small-molecule Stat3 dimerization inhibitor, S3I-M2001, is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011223661-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8969578-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11406707-B2 |
| priorityDate |
2006-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |