| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f285e3a97bead5bfd562a01a5347cffc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9cae989c6bd627633cf8ca57e26b4c2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2010-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fe0ed7e69d28266df95bd3ef7b0b6b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f25ca42ac4096a446b630a0a51b8179a |
| publicationDate |
2011-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011104789-A1 |
| titleOfInvention |
Non-integrating rev-dependent lentiviral vector and methods of using the same |
| abstract |
Non-integrating, Rev-dependent (NIRD) lentiviral vectors and NIRD lentiviral particles carrying a therapeutic gene, such as DT-A or TRAF6 and methods of making the same are disclosed. The intracellular expression of DT-A or TRAF6 results in the selective killing of HIV-positive cells and, thus, these NIRD lentiviral vectors and lentiviral particles can be used in methods to kill HIV-infected cells or treat to HIV-infected subjects. Also disclosed is a human cell line comprising a mutation in the EF2 gene that confers resistance to DT-A. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019083976-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016068919-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111263816-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104130331-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111471717-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104130331-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11129906-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113166782-A |
| priorityDate |
2009-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |