| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dee3727dba91e4e7aa3b26ce9efbcc21 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-147777 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-263
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-2632
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C17-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate |
2009-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbae88aad51a70e95d019c5f663ddde1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8363998c7837c655b2898274009724e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edcf69b5d6ddcf5a180a184a4c0a9e4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ae6a0c80bd06303ef75c4de5c483928 |
| publicationDate |
2011-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011098329-A1 |
| titleOfInvention |
Catalyzed carbonylation in the synthesis of angiotensin ii antagonists |
| abstract |
One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3′-(2′-halo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent. |
| priorityDate |
2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |