| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cffef6a2317cd32f038e41ec3b77500 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate |
2009-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b97f32edba86796c5e52e4620ad53f21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_814cd08ff799c8c171994a07c52ca530
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5b8f2c6d7a3240bef3b1db5ba25191f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0e08cc0d55a0c7dd75a29c7879e234e |
| publicationDate |
2011-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011087014-A1 |
| titleOfInvention |
Process for the manufacture of oligonucleotides |
| abstract |
A process for manufacturing an oligonucleotide which comprises removing β-eliminating phosphorus-protecting groups, in particular β-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters. |
| priorityDate |
2008-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |