| abstract |
NS1 variant polypeptides, proteins or functional fragments thereof are described which have useful properties for increasing viral protein synthesis, IFN induction, and IFN resistance. The NS1 variant polypeptides, proteins or functional fragments comprise a substitution in the amino acid sequence of the wild type NS1 protein at a position corresponding to Asp-2, Val-23, Leu-98, Phe-103, Ser-103, Met-106, Met-124, Asp-125, Val-180, Val-226 or Arg-227, or combinations thereof expressed alone or in infectious virus. |