http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011064828-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fc36fa6fc44c5ba1f66d4a77afdd80e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b21f650fc35b3e1947103e89adb06f3f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-063 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-24 |
| filingDate | 2010-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_452cf3b59aba9e9bb0d5e7d164893f36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1df73d854b5131a8d0d145f601db7d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ad96949ba55ec2a688bf50f739ef5f3 |
| publicationDate | 2011-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2011064828-A1 |
| titleOfInvention | Treatment of metastatic tumors and other conditions |
| abstract | The present invention generally relates to pharmacology and, in particular, to the treatment of tumors and other conditions. In some aspects, the invention is directed to the treatment of subjects having tumors or cancers that are metastatic. Surprisingly, it has been found that certain compositions comprising oxidized glutathione-based compounds are able to effectively treat such cancers by inhibiting cell migration and/or invasion processes, and thus, inhibiting tumor cell metastases. Without being bound by any theory, it is believed that such compositions are effective since the compositions are able to suppress the activation of critical signaling pathways within cells that are used for cell migration, such as the ErbB2 and/or phosphoinositide-3 kinase (PI3K) pathways, including the downstream RhoA and AKT pathways. Such pathways are regulated by ERp5, which is a protein disulfide isomerase regulated using certain redox pathways, and those redox pathways are unusually sensitive to treatment using oxidized glutathione-based compounds. Thus, the composition of the instant invention, in some embodiments, are surprisingly effective at preventing tumor metastases. While other references have disclosed the treatment of cancers using oxidized glutathione-based compounds, no reference has suggested that signaling pathways used for cell migration, invasion and metastasis, such as the ErbB2, PI3K, RhoA, and AKT pathways, are highly susceptible to treatment by altering the redox state of the cell, e.g., by oxidized glutathione-based compounds. Accordingly, the use of such compositions to treat tumor metastases is surprising and could not be predicted given the teachings of the prior art. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021008472-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I648051-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016129070-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11744853-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730756-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11491225-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013074822-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11389472-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018195111-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11357792-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105287370-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014071712-A1 |
| priorityDate | 2009-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1110.