| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61a7f6a9ed455a9d11716600339c2645 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-44 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4712
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2007-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff7de11d64a88cefa7ee144c6b2f2073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5479150fe44b6dd5c43a3601c6c55c7f |
| publicationDate |
2011-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011035819-A1 |
| titleOfInvention |
Codon optimized cftr |
| abstract |
A synthetic hCFTR DNA sequence has been developed that produces remarkably high levels of hCFTR mRNA and protein in dosed murine lungs and human cells in culture compared to the natural hCFTR cDNA. This synthetic DNA addresses problems inherent in some natural cDNAs, such as premature transcriptional truncation sites introduced during cDNA synthesis. Introns are initially present in mRNA until the mRNA is processed. cDNA made from processed mRNA is devoid of introns. Thus DNA sequences (exon junctions) are present in a cDNA molecule which are not present in cells in nature. These exon junctions may affect transcription. Methods for improving expression of CFTR are based on sequence changes in cDNA molecules. The improvement methods may be applied to other cDNA molecules which are refractory to in vivo expression efforts. Compositions embodying the sequence changes increase the production of both transgenic mRNA and protein from cDNA molecules. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11510937-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11214815-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015232878-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013119705-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10420791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010292307-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9713626-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107849565-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11253605-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10576166-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016286364-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11173190-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871503-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3446712-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11479768-B2 |
| priorityDate |
2006-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |