| abstract |
The use of compounds of formula (I) in therapy, particularly for the treatment of a disorder mediated by excessive or inappropriate HSP90 activity formula (I), wherein R 2 is a group of formula (IA): n —(Ar 1 ) m -(Alk 1 ) p -(Z) r -(Alk 2 ) S -Q (IA)n n Ar 1 , Alk 1 , Z, Alk 2 and Q being as defined in the specification; m, p, r and s are independently 0 or 1; R 3 is hydrogen, an optional substituent, or an optionally substituted (C 1 -C 6 )alkyl, aryl or heteroaryl radical; and R 4 is a carboxylic ester, carboxamide or sulfonamide group; or a salt, N-oxide, hydrate, or solvate thereof. |