abstract |
Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure n n n n n n n n n n wherein n R 1 , R 2 and R 4 , are as defined herein; n G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n n is an integer of 1 or 2; n m is an integer of 1 or 2; n Z is oxygen (—O—) or NR 4h ; n a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided. |