http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011015089-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1de51bfcd4099fd47ae92e8ed50b549c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0681 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-087 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2200-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502707 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B60-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 |
| filingDate | 2010-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5249990abbe24d88a998092f4b79933c |
| publicationDate | 2011-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2011015089-A1 |
| titleOfInvention | Methods and apparatus for the detection and differentiation of non-sialated proteins from sialated proteins in a fluid sample |
| abstract | The present invention is directed to methods and devices for detection of cerebrospinal fluid leaks by detection of the CSF protein beta-2 transferrin. The microfluidic devices and methods of the invention combine capture and specific labeling of transferrin from a sample with a subsequent step of isoelectric focusing to separate transferrin isoforms for detection. Microfluidic channels and chambers are patterned on a substrate, designed so that on one region (i.e., a microfluidic channel or chamber) of the substrate transferrin is selectively captured from the sample and labeled, and in a second region of the susbstrate, transferrin isoforms are separated using isoelectric focusing. Detection of two transferrin bands, indicating the presence of beta-2-transferrin, indicates the presence of CSF in the sample. The devices and methods of the invention provide a safe, efficient, and ultrarapid modality with high specificity and sensitivity for the detection of CSF in the acute care setting. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012288959-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014004622-A1 |
| priorityDate | 2009-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.