| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52a24331fe7882d8a0801155df05d542 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2008-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8498389abe83ba83033b8f72ff61ca72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34a37d827bf5c20a3f727f4001e0634e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9832ac9e07e50dbe8053e19efbee70cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5c73cf8e32c37cfabb958cc918c1650
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_618953ba79cc6dc7cabd430b1c991451 |
| publicationDate |
2011-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011008885-A1 |
| titleOfInvention |
Linear double-stranded rna molecule interfering with different target genes |
| abstract |
A linear double-stranded RNA molecule, which comprises two or more consecutively or convergently linked short interfering RNAs (siRNAs) each reducing the expression of one of different target genes, and a recombinant expression vector comprising double-stranded DNA sequence expressing the linear double-stranded RNA molecule are provided. The linear double-stranded RNA molecule or the recombinant expression vector is useful for a method of reducing expression of target genes in a cell, the method comprising introducing the linear double-stranded RNA molecule or the recombinant expression vector into the cell, whereby the encoded siRNAs target different genes and reduce expression of the target genes. It was also proved that effective gene silencing activity can be induced when each siRNA unit within the linear double-stranded RNA molecule has 18 to 24 nucleotides and, additionally, the gene silencing activity is not affected by inverted orientation of an siRNA. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015357165-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014249304-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9115167-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10443057-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012232126-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110770343-A |
| priorityDate |
2007-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |