| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f50de99a5d15fa865aef67b2fd70f218 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-01037 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2009-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f876f6cc836e4941132f62367e6cb60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c577d9c58f2a339de2301c8abf2256 |
| publicationDate |
2011-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011008451-A1 |
| titleOfInvention |
Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
| abstract |
Polymeric nanoparticles encapsulating inhibitory ribonucleic acids (RNAs) and methods of their manufacture and use are provided. Advantageous properties of the nanoparticles include: 1) high encapsulation efficiency of inhibitory RNAs into the nanoparticles, 2) small size of the nanoparticles that increases cell internalization, and 3) sustained release of encapsulated inhibitory RNAs by the nanoparticles that allows for administration of an effective amount of inhibitory RNAs to cells or tissues over extended periods of time. Encapsulation efficiency of inhibitory RNAs into the nanoparticles is greatly increased by complexing the inhibitory RNAs to polycations prior to encapsulation. Methods of using the polymeric nanoparticles for treating or inhibiting diseases or disorders are provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022261115-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021257262-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906503-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013082529-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3973955-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013102079-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9895451-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022026585-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023108083-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020257776-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020257779-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021022161-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016201031-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020033951-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017143042-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017143061-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014187469-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10682422-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023159189-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012064346-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018187493-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10465042-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017197128-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016081621-A1 |
| priorityDate |
2008-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |