| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f1173e8c4216a1d9b4790abf367aa3b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33cc881a94dae8218a64d8ed38007cd6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J2377-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L77-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G69-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 |
| filingDate |
2008-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a52edb3a601130ec02cd611b04d3f0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c509cae4ba600a049757fc4e3b0c96b |
| publicationDate |
2011-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2011008441-A1 |
| titleOfInvention |
Thermoresponsive arginine-based hydrogels as biologic carriers |
| abstract |
Cationic poly(ester amide) (PEA)-based hydrogels are provided. The hydrogels are fabricated from unsaturated L-arginine base poly(ester-amide) (UArg-PEA) precursors, pluronicDA precursors, or a combination of UArg-PEA and pluronicDA precursors at predetermined precursor composition ratios. PluronicDA/UArg-PEA hybrid hydrogels and pure pluronicDA based hydrogels are thermoresponsive and biodegradable, while pure UArg-PEA base hydrogels are biodegradable but not thermoresponsive. UArg-PEA based, pluronicDA based and hybrid hydrogels can be synthesized from unsaturated arginine-based PEA salts and/or unsaturated pluronic acid polymers. Unsaturated pluronic acid polymers can be synthesized by reacting pluronic acid with acryloylchloride to provided functional vinyl groups at the two chain ends of pluronic acid. The hydrogels can be used to carry and/or release molecules or compounds such as bioactive compounds, can function as biologic carriers for a variety of biomedical applications. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112521632-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020006317-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114716813-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020225322-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108743972-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10052283-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015231246-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3736304-A1 |
| priorityDate |
2007-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |