| abstract |
The present invention discloses pyridoindolobenzox- and thiazepine compositions of Formula 1, wherein n n n n n n n n n n A is —CH(R 9 )—X—, —XCH(R 9 )—; —CO—X— or —X—CO—; X is —O—, —S—, —SO—, or —SO 2 —. Y is a single bond or a double bond. D and E are independently —(CH 2 ) n —; and ‘n’ varies from 0 to 2. R 1 to R 9 are various electron donating, electron withdrawing, hydrophilic, or lipophilic groups selected to optimize the physicochemical and biological properties of compounds of Formula I. |