| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d42f684941d5b0617ca7764ebdff07 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a6d67230d113b367e2b29b78e8ff144
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8cf0b2b8c151e53be585482ad017fab |
| publicationDate |
2010-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010331390-A1 |
| titleOfInvention |
Effects of apolipoprotein b inhibition on gene expression profiles in animals |
| abstract |
Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10557137-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10883104-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109735541-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014179620-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014179625-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4119569-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9347061-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299736-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017079745-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11400161-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10570169-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9181550-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9163239-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9127276-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9181549-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10875884-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9932581-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9617331-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8916694-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013076730-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9382540-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957504-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017079739-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957292-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11319536-B2 |
| priorityDate |
2002-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |