| abstract |
There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) n n n n n n n n n n wherein R′ is selected from the group consisting of hydrogen, —C(O)OA, —C(O)CX 3 , —C(O)NH 2 , —C(O)—NHOH or n n n n n n n n n n There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib. |