Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 |
filingDate |
2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe90663cf967b55ede527631a56b46ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_189beddaebd257334afadc93dd8fedd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e03675c33d04aa98b9af48d39ad3955 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec9b2d6aea0641f4e5acca5efa7e1b49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea4b7081a25037292b5d60e7116d71b2 |
publicationDate |
2010-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2010311113-A1 |
titleOfInvention |
Chemo-enzymatic peptide synthesis via c-terminal ester interconversion |
abstract |
The invention relates to a method for preparing an optionally N-protected amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester, comprising transesterifying the C-terminal t-alkyl ester of the amino acid or the C-terminal t-alkyl ester of the peptide with an alcohol (other than the t-alcohol corresponding to the t-alkyl group of the ester) in the presence of a hydrolytic enzyme (E.C. 3). n The invention further relates to a method for preparing a peptide comprising coupling an activated, N-protected, amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester with an optionally C-terminal protected amino acid or an optionally C-terminal protected peptide via a peptide bond, in the presence of an enzyme catalysing peptidic bond formation. |
priorityDate |
2007-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |