Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4e0fcf309b0d49f890b63cfe2018d4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b013972096cb829c50a031edc741396d |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
filingDate |
2007-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_593727d8e5104004ed34da024f733281 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff670795d4f9687e75866c320f8b3bd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aa17f63ab8a2f22841d1fd93de6f189 |
publicationDate |
2010-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2010310521-A1 |
titleOfInvention |
Polynucleotide sequence for the inhibition of phospholamban synthesis |
abstract |
A DNA polynucleotide sequence is disclosed that comprises a transcribed sequence, and a promoter sequence. Transcription of the transcribed sequence by an RNA polymerase in a cell renders an RNA a transcript capable of forming a partially self-complementary hairpin structure which can be processed by the cell to an siRNA product that can degrade phospholamban mRNA in such cell. The promoter is a drug inducible conditional promoter or a cardiomyocyte cell-specific promoter or both, operably linked to the transcribed sequence. The promoter is operable by an RNA polymerase naturally occurring in a mammalian cell. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9439924-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9795690-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9181556-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015157306-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10300147-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011247088-A1 |
priorityDate |
2006-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |