| abstract |
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. n The carboxamide compounds are compounds of the general formula I n n n n n n n n n n in which R 1 , R 2 , R 3a , R 3b , W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a′ and I-A.a″ n n n n n n n n n n in which m, E, R 1 , R 3a , R 3b , R 2 , R y , R w and R w6 * have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof. |