| abstract |
There is provided a compound having Formula I n n n n n n n n n n whereinn each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are independently selected from (a) H, (b) R 13 , —OC(R 13 ) 3 , —OCH(R 13 ) 2 , —OCH 2 R 13 , C(R 13 ) 3 , —CH(R 13 ) 2 , or —CH 2 R 13 wherein R 13 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) —SO 2 -alkyl; and (n) —N(R 14 )C(O)R 15 , wherein R 14 and R 15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C 1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C 1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0, S(═O) 2 , C═O, S(═O) 2 NR 16 , C═ONR 17 , NR 18 , in which R 16 , R 17 , and R 18 are independently selected from H and hydrocarbyl, R 10 is selected from H and hydrocarbyl, R 11 is selected from CR 19 R 20 and C═O, in which R 19 and R 20 are independently selected from H and hydrocarbyl, R 12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups. |