| abstract |
A process for producing an enantiomerically enriched, pure or enriched and essentially pure compound of Formula I: n n n n n n n n n n wherein the R-, or S-configuration at the stereogenic center is marked with an *; which process hydrogenates an enamide compound of formula III: n n n n n n n n n n in an organic solvent in the presence of a transition metal precursor complexed to a chiral phosphine ligand catalyst;n wherein Ar is phenyl which is unsubstituted or substituted; Z is OR 1 , SR 1 and NR 1 R 2 ; and P is R 3 , OR 3 , and NR 3 R 4 ; R 1 and R 2 are selected from H, C 1-8 alkyl, C 5-12 cycloalkyl, aryl and aryl-C 1-2 -alkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a C 4-7 -member heterocyclic ring system optionally fused with a 5- to 6-member carbocyclic or heterocyclic ring system; and R 3 and R 4 are selected from H, C 1-8 alkyl, aryl, C 5-12 cycloalkyl and aryl-C 1-2 -alkyl; or R 3 and R 4 together with the nitrogen atom to which they are attached form a C 4-7 -member heterocyclic ring system. |